Università di Valencia: studio conferma l'influenza genetica sul consumo di alcol nella popolazione occidentale
GENETIC COMPONENT OF ALCOHOL CONSUMPTION IN WESTERN POPULATIONS
How much alcohol you drink and how hard it affects you are rooted in your DNA. Much studied in Asian populations, this study at the University of Valencia contributes conclusive evidence to an emerging Western scientific literature on the subject.
A study carried out at the Universitat de València (University of Valencia, UV) has underlined the genetic component to the consumption and effects of alcohol. Specifically, it points to a "lazy" variant of the alcohol dehydrogenase 1B (ADH1B) gene, known to regulate the activity of a key group of enzymes.
When drinking, alcohol rushes into the bloodsteam, where alcohol dehydrogenase enzymes metabolise the ethanol into acetaldehyde. If this happens quickly, lots of acetaldehyde accumulates in a short amount of time, which can lead to adverse effects such as flushing, nausea, and headaches. Conversely, if the ethanol is metabolised slowly, the alcohol remains intact in the blood for longer periods, prolonging its more pleasant, euphoric effects.
The speed at which this process takes place, the metabolic rate of ethanol, is where the ADH1B gene comes in. A super-efficient gene can make the effects of alcohol more unpleasant, while carriers of a "lazy" variant enjoy longer highs. This may influence the tendency of carriers of one or the other variant to drink more or less alcohol.
Francesc Francés, at the Department of Legal and Forensic Medicine at the UV, says, "The main conclusion of this work is that this genetic polymorphism [the different variants of ADH1B carried by different people] seems to be linked to levels of alcohol consumption," adding that "this association is even more evident in the male population, perhaps due to the existence of fewer inhibiting social stereotypes".
The link between the "lazy" variant of the ADH1B gene and a greater alcohol consumption has long been proven by science within Asian populations. This study is one of the first to offer conclusive proof that it is also the case in the West.
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copia integrale del testo si può trovare al seguente link:
http://medicalxpress.com/news/2016-01-genetic-component-alcohol-consumption-western.html
(Articolo pubblicato dal CUFRAD sul sito www.alcolnews.it)